Z. Snyder, W. J. Differential Gene Expression. Moreover, we found a negative association between the decreased intranetwork FC of the bilateral precuneus and low-density lipoprotein levels in DR patients. The typical spatial patterns in each RSN of both DR and HC groups, including BGN, VN, vDMN, rECN, SN, lECN, AN, SMN, and dDMN. The MRI data used to support the findings of this study are available from the corresponding author upon request. We investigated relationships between distinct intranetwork FCs in brain regions and clinical variables (visual function and biochemical examination) in the DR group. Our results offer important insights into the neural mechanisms of visual loss and cognitive decline in DR patients. Based on a nerve's capacity for axonal transport, it may be visualized by targeted application of a contrast agent and assessing the distribution through radiological imaging, thus revealing a nerve's continuity. demonstrated that T2DM patients showed decreased degree centrality in the left lingual gyrus and increased centrality in the right insula and dorsal anterior cingulate cortex in the SN . Hunger? Our results provide useful information to better understand the neural mechanisms that affect DR patients. We are committed to sharing findings related to COVID-19 as quickly as possible. The genetic structure and post-glacial dispersal of these species are not well known. The main pathological changes in DR are retinal capillary nonperfusion, as well as vascular leakage and degeneration. Webseite . Low-level perceptual and higher-order cognitive networks engage in organized patterns of correlated activity forming resting-state networks (RSNs) [18–20].  P. Chen, T. Pavlidis, Image segmentation as an estimation ... 574–585. 219–223. We had 5 different dishes as family, all were great, fresh prepared and tasty, positive was that the kids menu was the first served. Sun, and L. Ma, “Mapping the brain in type II diabetes: voxel-based morphometry using DARTEL,”, M. Desmurget, S. T. Grafton, P. Vindras, H. Grea, and R. S. Turner, “Basal ganglia network mediates the control of movement amplitude,”, H. H. Yin, S. B. Ostlund, and B. W. Balleine, “Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks,”, R. C. O'Reilly and M. J. Frank, “Making working memory work: a computational model of learning in the prefrontal cortex and basal ganglia,”, M. Arsalidou, E. G. Duerden, and M. J. Taylor, “The centre of the brain: topographical model of motor, cognitive, affective, and somatosensory functions of the basal ganglia,”, A. M. Graybiel, T. Aosaki, A. W. Flaherty, and M. Kimura, “The basal ganglia and adaptive motor control,”, S. Lehéricy, E. Bardinet, L. Tremblay et al., “Motor control in basal ganglia circuits using fMRI and brain atlas approaches,”, K. Szewczyk-Krolikowski, R. A. Menke, M. Rolinski et al., “Functional connectivity in the basal ganglia network differentiates PD patients from controls,”, M. Duan, X. Chen, H. He et al., “Altered basal ganglia network integration in schizophrenia,”, H. Cho, J. H. Kim, C. Kim et al., “Shape changes of the basal ganglia and thalamus in Alzheimer's disease: a three-year longitudinal study,”, J. Y. Li, T. Y. Yong, R. Sebben, E. Khoo, and A. P. Disney, “Bilateral basal ganglia lesions in patients with end-stage diabetic nephropathy,”, E. J. Lee, J.-H. Park, Y. k. Ihn, Y. J. Kim, S. K. Lee, and C. S. Park, “Acute bilateral basal ganglia lesions in diabetic uraemia: diffusion-weighted MRI,”, M. E. Raichle, A. M. MacLeod, A. Furthermore, DR patients exhibit abnormalities in the visual cortex. All the subjects were instructed to rest quietly with their eyes closed and relaxed without thinking about anything in particular or falling asleep. There is growing evidence that diabetes patients exhibit abnormal FC of the DMN, which is correlated with cognitive decline [65–67]. reported that type 1 diabetes mellitus patients showed decreased white matter in the left temporal lobe . (2) The remaining 230 volumes of functional BOLD images were corrected for slice timing effects, motion corrected. demonstrated that decreased gray matter density in the right inferior frontal gyrus and right occipital lobe was observed in DR patients, relative to healthy controls (HCs) . Independent component analysis (ICA) is a powerful data-driven approach for finding independent patterns in multivariate data; the ICA method is used to identify multiple RSNs and investigate intra- and internetwork functional connectivities (FCs) in vivo [23, 24]. Restaurants near Fischamend Station, Fischamend on Tripadvisor: Find traveller reviews and candid photos of dining near Fischamend Station in Fischamend, Austria. contributed to data collection and statistical analyses and wrote the manuscript. However, little is known regarding whether the functional architecture of resting-state networks (RSNs) changes in DR patients. Ambulance & Rescue. In future studies, we plan to enlarge the sample size. Chen et al. Dienstag-Samstag,sowie an Feiertagen: 11:30-15:00 Uhr 17:30-22:00 Uhr. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. The abovementioned studies mainly focused on local functional and structural changes in the brains of DR patients. designed the protocol and reviewed and edited the manuscript. We would like to thank Mr Li Zhengyue and Mr Chen Deyi for their help in designing and manufacturing the sampling equipment and laboratory room, and Mr. Xiang Tongshou for technical assistance and GC-MS data acquisition. Scale represents, Brain regions with significant differences for eight RSNs in the DR group vs. the HC group (two-tailed, voxel-level, Note: the statistical threshold was set at the voxel level with. Mr. Chen's Chinese Restaurant offers authentic and delicious tasting Chinese cuisine in Homewood, AL. Specifically, the AUC for left IPL of the right executive control network (0.887) and for left STG of the auditory network (0.899) showed high sensitivity. Abnormal FCs among the ECN, DMN, and SN have been shown to contribute to cognitive decline in Alzheimer’s disease patients . The study of brain connectivity is characterized by a multifaceted approach providing both structural and functional evidence of the relationship between cerebral regions at different scales. A Pearson correlation coefficient was conducted to assess the relationships between the intranetwork FC values of different brain regions and clinical variables in the DR group using SPSS version 20.0 software (SPSS Inc., Chicago, IL, USA). Components retained for further analysis among the 26 estimated ICs were selected based on the largest spatial correlation with specific RSN templates [37, 38]. Asia Restaurant Mr Liao, 2325 Himberg, Hauptstrasse 59 Tel. 182 people like this. Eat local and support your community - Best Chinese in 7100 Neusiedl am See, Austria - Asia Restaurant Mandarin, China-Restaurant China Town, China-Restaurant Jing's, China-Restaurant Mandarin, Chinarestaurant Mandarin, Asia-Restaurant YU, Stammhaus, China-Restaurant Asia, China Restaurant Hainburg Hu Xiao Juan, Zum goldenen Fisch, China-Restaurant Himberg, GAO Ping, China Restaurant … 26 check-ins. Mr Chen: Fresh cooked and tasty - See 14 traveler reviews, 4 candid photos, and great deals for Vienna, Austria, at Tripadvisor. This is the version of our website addressed to speakers of English in the United States. Abstract. Two-sample -tests were used to compare distinct temporal relationships between RSNs between the two groups (, uncorrected). However, the ICA method has not been applied to characterize changes in RSNs in DR patients. Consistent with these findings, our results revealed decreased intranetwork FCs in the left superior temporal gyrus and right superior temporal gyrus of the AN, implicating impaired auditory function in DR patients. Thus, visual loss is an important clinical manifestation in DR patients. Mr Chen: immer wieder gut! DR patients showed decreased putamen and right thalamic volume relative to HCs . Eliza Carrano. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. One-sample -tests were used to compare temporal relationships between RSNs for each group (, uncorrected). Importantly, the retinal vasculature shares similar anatomic, physiological, and embryological characteristics to cerebral vessels . The AN is located in the temporal lobe, which plays an important role in processing auditory information. Sonntag: 11:30-22:00 Uhr. Some limitations should be acknowledged in this study. The DMN consists of several brain regions including the medial prefrontal cortex, posterior cingulate cortex, inferior parietal cortex, and precuneus . There are several risk factors for DR, such as a higher hemoglobin (HbA1c) level , longer duration of diabetes , and hypertension . This work was supported by the Chinese National Natural Science Foundation (No. Moreover, Low-density lipoprotein in DR patients was negatively correlated with the intranetwork FC values of the bilateral MOG (, ). This review is the subjective opinion of a TripAdvisor member and not of TripAdvisor LLC. Naidu et al. Copyright © 2020 Xin Huang et al. However, it is largely unknown how large-scale neuronal networks are affected by DR. Low-frequency fluctuations (<0.01 Hz) in the blood oxygenation level-dependent signal during rest reflect spontaneous neural activity, which can be conceptualized as a network of anatomically linked regions. 6:04 Himberg b.Wien Hauptplatz 6:26 Bus 368 Jetzt geschlossen. Note: ROC curve in intranetwork FC values: DR < HC, for B-THA, 0.776 (, Large-Scale Neuronal Network Dysfunction in Diabetic Retinopathy, Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China, Medical Research Institute, Wuhan University, Wuhan, 430071 Hubei, China, X. Zhang, J. Community See All. Place with typical decorations completely empty on Sunday late afternoon, I was almost about to turn around based in rule no guest not that good kitchen, but it was between lunch time and dinner so I said we try as kids were quite hungry. Freshwater fishes of the genus Esox are found throughout the Holarctic region. Thus, we speculate that DR patients might demonstrate impaired attentional and working memory function. Significant decreased intranetwork FC within RSNs was identified in the DR group relative to the HC group (Figure 2 and Table 2). A. Willette, G. Xu, S. C. Johnson et al., “Insulin resistance, brain atrophy, and cognitive performance in late middle-aged adults,”, E. A. Northam, D. Rankins, A. Lin et al., “Central nervous system function in youth with type 1 diabetes 12 years after disease onset,”, Z. Chen, L. Li, J. Sign up here as a reviewer to help fast-track new submissions. The IC time courses and spatial maps for each subject were transformed to -scores. B. Saaddine, C. F. Chou et al., “Prevalence of diabetic retinopathy in the United States, 2005-2008,”, J. W. Y. Yau, S. L. Rogers, R. Kawasaki et al., “Global prevalence and major risk factors of diabetic retinopathy,”, G. Jin, W. Xiao, X. Ding et al., “Prevalence of and risk factors for diabetic retinopathy in a rural Chinese population: the Yangxi Eye Study,”, S. Samaiporn, P. Lertmeemongkolchai, T. Chongwiriyanurak, P. Anujaree, D. Chayaboon, and A. Pohikamjorn, “Prevalence of diabetic retinopathy in relation to duration of diabetes mellitus in community hospitals of Lampang,”, J. ICA was applied to extract the nine RSNs. The group spatial maps of RSN were visualized using the Resting-State fMRI Data Analysis Toolkit plus V1.2 (RESTplus V1.2, http://restfmri.net/forum/RESTplusV1.2). To the best of our knowledge, this is the first study to investigate whether the intranetwork FCs and FNCs of RSNs change in DR patients. Diabetic retinopathy (DR) patients are at an increased risk of cognitive decline and dementia. 26 IC maps were estimated in this study. Compared to the HC group, DR patients showed significant decreased intranetwork FCs within the basal ganglia network (BGN), visual network (VN), ventral default mode network (vDMN), right executive control network (rECN), salience network (SN), left executive control network (lECN), auditory network (AN), and dorsal default mode network (dDMN). 10 months ago on Google. Поръчай сладолед в Himberg в много ресторанти, например в Asia Restaurant Mr. Chen, Erkus Döner Pizza Schnitzel, Euro Imbiss или Solemio Pizzeria. Y.T., C.X.Q., H.D.D., and Q.Q.D. The activation of SN has been detected during attentional, working memory, and response-selection paradigms , which are involved in switching between the ECN and DMN . Restaurants in der Nähe von Lanzendorfer Straße in Himberg Diese Website erhebt und speichert Ihre anonymisierte IP-Adresse (siehe Datenschutz ) und verwendet Cookies. Basal and stimulated endothelium-dependent forearm blood flow responses in hypercholesterolemic subjects are improved in 4 wk of treatment with statin ().Simvastatin has been reported to increase endothelial NO production and improve NO-dependent vasorelaxation in different vascular beds (15, 16). Nine RSNs were identified in this study: basal ganglia network (BGN), visual network (VN), ventral default mode network (vDMN), right executive control network (rECN), salience network (SN), left executive control network (lECN), auditory network (AN), sensorimotor network (SMN), and dorsal default mode network (dDMN). - Auf Tripadvisor finden Sie 14 Bewertungen von Reisenden, 4 authentische Reisefotos und Top Angebote für Wien, Österreich. In addition, several neuroimaging studies have revealed that diabetes patients exhibit temporal lobe atrophy. Fetal exposure to drugs cannot be readily estimated from single time point cord blood sampling at the time of delivery. In conclusion, our results revealed that DR patients had widespread deficits in both low-level perceptual and higher-order cognitive networks, which suggest potential impairments in visual, auditory, and cognitive functions in DR patients. This step was repeated 100 times using the ICASSO algorithm to assess the repeatability or stability of ICs . Willette et al. Asia Restaurant Mr. Liao, Himberg. There are increasing reports that abnormalities in the BGN are present in central nervous system diseases, including Parkinson’s disease , schizophrenia , and Alzheimer’s disease . 2020, Article ID 6872508, 13 pages, 2020. https://doi.org/10.1155/2020/6872508, 1Eye Center, Renmin Hospital of Wuhan University, Wuhan, 430060 Hubei, China, 2Medical Research Institute, Wuhan University, Wuhan, 430071 Hubei, China. Therefore, we developed a physiologically based pharmacokinetic (PBPK) model to estimate fetal drug exposure throughout pregnancy. The typical spatial patterns in each RSN of both DR and HC groups are illustrated in Figure 1. Öffnet in 6 h 51 min. MRI scanning was performed on a 3-tesla magnetic resonance scanner (Discovery MR750W system; GE Healthcare, Milwaukee, WI, USA) with an eight-channel head coil. Collection of indviduals. reported that type 1 diabetes patients with proliferative retinopathy showed lower eigenvector centrality mapping and degree centrality in the bilateral thalamus and dorsal striatum, as well as increased eigenvector centrality mapping in the occipital cortex . The exclusion criteria for DR patients were (1) the presence of proliferative DR with retinal detachment; (2) the presence of vitreous hemorrhage; (3) the presence of additional ocular-related complications (cataract, glaucoma, high myopia, or optic neuritis); and (4) the presence of diabetic nephropathy or diabetic neuropathy. In addition, DR causes retinal neurodegeneration . Recent advances in magnetic resonance imaging approaches have provided a powerful framework for the characterization of central nervous system changes in DR. 93 meters 4horse & dog - Michaela Bauer. Demographics and visual measurements between two groups. Third, the ICs for each subject were derived from the group ICA back-reconstruction step and were converted into -scores . Chen 30627 Hannover-Misburg-Nord Öffnungszeiten Adresse Zhengfeng Chen Asia Restaurant Mr. Chen in Hannover im Branchenbuch von meinestadt.de - Telefonnummer, Adresse, Stadtplan, Routenplaner und mehr für Zhengfeng Chen Asia Restaurant Mr. Chen Hannover Deftig, modern oder klassisch - bei uns kommt Gutes auf den Tisch! Consistent with the findings of the prior studies, we found that DR patients showed decreased intranetwork FCs of the bilateral inferior parietal lobule, right superior medial frontal gyrus, and left superior frontal gyrus of the ECN. There is growing evidence that DR patients exhibit greater cognitive impairment than those with advanced DR. The total cholesterol of DR patients showed a negative correlation with the intranetwork FC values of left STG (; ) (Figure 4(d)). There is growing evidence that impaired auditory function is present in diabetes patients [43–46]. Dai et al. We selected 26 meaningful ICs by using the following criteria: (a) peak coordinates of spatial maps located primarily in the gray matter, (b) no spatial overlap with vascular, ventricular, or susceptibility artifacts, and (c) time courses dominated by low-frequency signals (ratio of powers below 0.1 Hz to 0.15-0.25 Hz in the frequency spectrum). However, the etiology of the neurophysiological mechanism of this increased risk is unclear. Flickr is almost certainly the best online photo management and sharing application in the world. For head motion parameters, more than 2 mm or for whom rotation exceeded 1.5° during scanning was excluded . There is growing evidence that DR patients are at high risk of stroke  and cerebral microbleeds . demonstrated that abnormal RSNs of the default mode, left frontal parietal, and sensorimotor networks were detected in T2DM patients . Closed Now. Thirty-four DR patients (18 men and 16 women; mean age, years) and 38 nondiabetic healthy controls (HCs) (15 men and 23 women; mean age, years), closely matched for age, sex, and education, underwent resting-state magnetic resonance imaging scans. Consistent with these findings, our results revealed that DR patients showed significantly decreased intranetwork FCs in the bilateral precuneus, left posterior cingulate gyrus, and left superior medial frontal gyrus of the DMN, which suggests cognitive decline in DR patients. In addition, retinal microvascular abnormalities constitute useful clinical biomarkers for cognitive decline in patients with diabetes . It turned to be very pleasant family restaurant. This work was supported by the Chinese National Natural Science Foundation (No. These are followed by proliferative retinal detachment and eventual blindness. reported that increased retinal venular tortuosity was related to cognitive decline in patients with type 2 diabetes mellitus (T2DM) . Zoom in to see updated info. The meals are freshly cooked, the prices are moderate and service is excellent. There were no significant differences in the gender, age, and weight between the groups (Table 1). Introduction: Current imaging modalities for peripheral nerves display the nerve's structure but not its function. All preprocessing was performed using the toolbox for Data Processing & Analysis of Brain Imaging (DPABI, http://www.rfmri.org/dpabi)  which is based on Statistical Parametric Mapping (SPM12) (http://www.fil.ion.ucl.ac.uk) implemented in MATLAB 2013a (MathWorks, Natick, MA, USA) and briefly the following steps according to our previous study : (1) DICOM format of the functional images was converted to NIFTI format, and the first ten volumes of each subject were removed due to the signal reaching equilibrium. Thus, we speculated that DR patients would exhibit an impaired VN and that the higher Low-density lipoprotein level would be closely correlated with abnormalities in the VN in DR patients. Previous neuroimaging studies demonstrated that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. 23:13 Himberg b.Wien 23:25 R 7648V K 23:36 Wien Grillgasse 23:36 Fußweg (4 Min.) Ozsoy et al. There was significant difference in BCVA-OD () and BCVA-OS (). Prior studies demonstrated that basal ganglia lesions occurred in diabetic nephropathy and diabetic uremia patients, indicating potential movement disorders in diabetes patients [59, 60]. The FNC toolbox was used to assess interactions among RSNs. Second, all data from each subject were reduced; the compressed datasets of each subject were concatenated into a single group, and this aggregate dataset was further reduced to 26 components using principal component analysis, followed by IC estimation using the Infomax algorithm . Jue is known for his performances on Broadway, in national tours, Off-Broadway and in regional theatre, particularly in the San Francisco Bay Area and at The Muny in St. Louis.His roles in … Our study demonstrated that DR patients had decreased intranetwork FC of the bilateral anterior cingulate gyrus of the SN. Previous studies demonstrated that the basal ganglia play a critical role in motor control [54, 55]. Thus, our results suggest that DR patients might also exhibit cognitive decline. Lin W, Zhu Q, Gao W, Chen Y, Toh C-H, Styner M, Gerig G et al. Third, RSN values based on blood oxygenation level-dependent signals would still be affected by physiological noise, such as cardiac and respiratory activity. In recent years, brain connectivity is gaining ever-increasing interest from the interdisciplinary research community. The DMN is regarded as an endogenous neural network that shows consistently higher blood oxygenation level-dependent activity during rest; it plays an important role in self-referential thought and introspection . Show off your favorite photos and videos to the world, securely and privately show content to your friends and family, or blog the photos and videos you take with a cameraphone. DR patients also exhibit brain structural alterations. The mask was created by combining the regions of corresponding RSNs in both DR patients and HCs, which were obtained from one-sample -test results. Based on this hypothesis, the purpose of this study was to determine whether DR patients exhibited intranetwork FCs and functional network connectivities (FNCs) associated with changes in RSNs. 81800872) and International Science and Technology Cooperation Programme of China (2017YFE0103400). Chen, Di, "Applications of Acoustic Techniques to Targeting Drug Delivery and Dust Removal Relevant to NASA Projects" (2010). Group comparisons were masked to the voxels within corresponding RSNs (two-tailed, voxel-level ; Gaussian random field correction, cluster-level ). Object This study investigates the effect of tumor location on alterations of language network by brain tumors at different locations using blood oxygenation level dependent (BOLD) fMRI and group independent component analysis (ICA). Pet Groomer. The decreased intranetwork FCs of RSNs were correlated with clinical variables in the DR group. All subjects provided written informed consent to participate in the study. All HCs met the following criteria: (1) mmol/L, mmol/L, and ; (2) no ocular diseases (myopia, cataracts, glaucoma, optic neuritis, or retinal degeneration); (3) (decimal); (4) no ocular surgical history; and (4) no mental disorders. Subjects and Methods BOLD fMRI data were obtained from 43 right handed brain tumor patients. In addition, neuroimaging studies revealed that T2DM patients showed impaired ECN relative to nondiabetic HCs . They did not have menius in English, but it wasn’t a problem since the employees/owners were willing to help! Best Asian Restaurants in Himberg, Lower Austria: Find Tripadvisor traveller reviews of Himberg Asian restaurants and search by price, location, and more. demonstrated that DR patients showed decreased N-acetyl-aspartate/creatine and N-acetyl-aspartate/choline ratios in the visual cortex, relative to HCs . Water Res 23 (8): 979–984. Wir freuen uns auf Ihren Besuch! If you are a resident of another country or region, please select the appropriate version of Tripadvisor for your country or region in the drop-down menu. We presume that the lipid metabolism level might affect cognitive function in DR patients. demonstrated that DR patients had abnormal brain local functional networks related to visual function and cognition . Statistical significance thresholds were set at (false discovery rate- (FDR-) corrected). van Duinkerken et al. reported that T2DM patients showed decreased gray matter volume in medial temporal, anterior cingulate, and medial frontal lobes, which were related to poor visuospatial construction, planning, and visual memory . Arrows represented a significant correlation between RSNs. ... ASIA RESTAURANT MR. CHEN: Jingfeng Chen: Mo – So: 11:00 – 14:30 Uhr & 17:30 – 22:00 Uhr, Kein Ruhetag: Hauptstraße 1 +43 2235 40942: van Duinkerken et al. Restaurants near Felmayer's Gastwirtschaft, Schwechat on Tripadvisor: Find traveller reviews and candid photos of dining near Felmayer's Gastwirtschaft in Schwechat, Austria. designed the protocol and contributed to MRI analysis. Mr Chen's Chinese Cooking | (205) 824-8283 1917 Hoover Ct, Birmingham, AL 35226 The BGN are activated for specific functions and circumstances, including movement control , associative learning , working memory , and emotion . For sure we will come back again. ☛ Sushi bestellen Himberg 2435! Our findings might provide new insights into underlying neural mechanisms in DR. Thirty-four DR patients (18 men and 16 women; mean age, years) and 38 nondiabetic HCs (15 men and 23 women; mean age, years), matched for age, sex, and education, participated in this study. Henry Himberg, Yuichi Motai, Latency and Distortion of Electromagnetic Trackers for Augmented Reality Systems, Synthesis Lectures on Algorithms and Software in Engineering, 10.2200/S00580ED1V01Y201404ASE012, 6, 1, (1-189), (2014). Mr Chen: Immer wieder gerne!!! Jingfeng Chen. donn waß i wos daham san wie da grado und da mr. chen// i schick an gruaß über maria nach himberg auße// owa nirgends is’ so sche wie do, es stimmt, drum glaubts es// weul die leit die san a wahnsinn und die gegend is’ ned schlecht// 2333, i geh do nimma weg// [refrain: kugelblitz] des … Deli Kebap & Pizzahaus - Sen Nesimi. 5. Disaster Relief. Moreover, the DR group showed increased VN-BGN, VN-vDMN, VN-dDMN, vDMN-lECN, SN-BGN, lECN-dDMN, and AN-BGN FNCs, relative to the HC group. Then, two-sample -tests were conducted to investigate different intranetwork FCs within nine RSNs between the two groups. SPRECHSTUNDEN BÜRGERMEISTER FRITZ BLASNEK. The purpose of this study was to investigate the intranetwork functional connectivity (FC) and functional network connectivity (FNC) of RSN changes in DR patients using independent component analysis (ICA). There is accumulating evidence that specific functional and structural architecture changes in the brain are related to cognitive impairment in DR patients. Studies in humans and animals have demonstrated a positive effect of statins on endothelial function. reported that type 1 diabetes mellitus patients with proliferative retinopathy showed lower local clustering in the middle frontal, postcentral, and occipital areas . The ROC curve in intranetwork FC values are the following: DR < HC, for bilateral THA, 0.776 (; 95% CI: 0.670-0.882); for right CAU, 0.843 (; 95% CI: 0.749-0.937) (Figure 5(a)); for bilateral MOG, 0.835 (; 95% CI: 0.744-0.926) (Figure 5(b)); for bilateral PreCUN, 0.839 (; 95% CI: 0.747-0.932) (Figure 5(c)); for right IPL, 0.787 (; 95% CI: 0.684-0.889); for left IPL, 0.887 (; 95% CI: 0.807-0.966); for left SMFG, 0.781 (; 95% CI: 0.676-0.885) (Figure 5(d)); for bilateral ACC, 0.801 (; 95% CI: 0.698-0.903) (Figure 5(e)); for left SFG, 0.804 (; 95% CI: 0.705-0.902) (Figure 5(f)); for left STG, 0.899 (; 95% CI: 0.831-0.967); for left STG, 0.817 (; 95% CI: 0.720-0.913) (Figure 5(g)); for left PCC, 0.778 (; 95% CI: 0.666-0.889); and for left SMFG, 0.791 (; 95% CI: 0.689-0.893) (Figure 5(h)). Yafen Chen, Yoon-Hee Cha, Chuang Li, Guofa Shou, Diamond Gleghorn, Lei Ding, Han Yuan, Multimodal Imaging of Repetitive Transcranial Magnetic Stimulation Effect on Brain Network: A Combined Electroencephalogram and Functional Magnetic Resonance Imaging Study, Brain Connectivity, 10.1089/brain.2018.0647, (2019).